Guardians vs. Rays Predictions, Picks & Odds for ALCS Game 6

The ALCS returns to St. Petersburg, Florida, Monday night as the Tampa Bay Rays host the Cleveland Guardians for Game 6 at Tropicana Field. The Rays have a chance to punch their ticket to the World Series to face Milwaukee with a win.

The Rays trailed 2-1 in the series but won two consecutive road games in Cleveland over the weekend to take a 3-2 lead heading back home to the Trop. Tampa Bay earned a 7-3 win in Game 4 on Saturday to even the series at two games apiece before securing a 3-1 victory in Game 5 on Sunday. The Rays scored one run in each of the first three innings of Game 5 and got excellent pitching from All-Star right-hander Drew Rasmussen, who allowed just four hits and one run over seven innings.

Veteran right-hander Freddy Peralta will look to do more of the same as the Rays’ starter for Game 6 Monday night. After a terrific final month of the regular season, Peralta has carried that success into the postseason, allowing only one run over 11.1 innings across three appearances. He tossed six scoreless innings and picked up the win in Game 2 of the ALCS before most recently coming out of the bullpen in Game 4 on Saturday to record the final two outs of the sixth inning.

The Guardians are expected to counter with right-handed reliever Shawn Armstrong as the opener. Armstrong made his first career MLB playoff start in Game 4, pitching a scoreless first inning before being replaced on the mound. He also made a scoreless appearance out of the bullpen in Game 5, tossing 1.1 innings of relief. The veteran has yet to allow a run in six appearances this postseason.

Find Guardians vs. Rays predictions, picks, and more below ahead of Monday night’s ALCS Game 6 at Tropicana Field.

Guardians vs. Rays Odds for Game 6

The Rays have momentum on their side and are listed as home favorites at Hard Rock Bet Sportsbook:

• Moneyline: Rays -155, Guardians +130
• Run Line: Rays -1.5 (+145), Guardians +1.5 (-180)
• Total (Runs): Over 6.5 (-120), Under 6.5 (+100)

Guardians vs. Rays ALCS Winner Odds

Tampa Bay is one win away from a World Series appearance and will have two opportunities at home to make that happen. Hard Rock Bet Sportsbook lists the Rays as sizable favorites to win the ALCS over the Guardians:

• Rays to Win ALCS: -450
• Guardians to Win ALCS: +350

Guardians vs. Rays Predictions

The pressure is on, with the Guardians facing elimination Monday night while the Rays look to get the job done and avoid a winner-take-all Game 7. If you’re looking to get involved in the action, Hard Rock Bet Sportsbook has you covered with a wide range of baseball betting markets as well as its Stats Hub, which provides useful insights to help make more informed picks like our Guardians vs. Rays prediction below:

Rays vs. Guardians Best Bet: Under 0.5 1st Inning Total Runs (-160)

There has been at least one run scored during the first inning in three of the first five games of the ALCS, including Games 4 and 5. However, the Stats Hub notes that there has been no run scored during the first inning in seven of the Guardians’ last eight games at Tropicana Field, where Game 6 will take place Monday night.

The expected starting pitchers also play a major role in this No Run First Inning (NRFI) pick. Rays starter Freddy Peralta has allowed four total runs over his last nine appearances dating back to the regular season, while Shawn Armstrong has yet to allow a run over 7.2 innings for the Guardians this postseason. As mentioned above, Armstrong also tossed a scoreless first inning against the Rays when he opened Game 4.

• Rays vs. Guardians NRFI Pick for ALCS Game 6: Under 0.5 1st Inning Total Runs (-160)

Top 5 Most-Bet Player Props for CLE-TB

Rays designated hitter Yandy Díaz made headlines following Sunday’s 3-1 victory in Game 5, all but guaranteeing that the series will come to a close Monday night with Tampa Bay winning and advancing to the World Series. Whether that happens remains to be seen, but he’s a popular target in the player prop markets, with his hits prop being the most-bet for Game 6:

1. Yandy Díaz – Over 0.5 Hits
2. Junior Caminero – Over 0.5 Hits
3. Steven Kwan – Over 0.5 Hits
4. José Ramírez – Over 0.5 Hits
5. Chandler Simpson – Over 0.5 Hits

Guardians vs. Rays Betting Splits for Game 6

Here’s how the action is trending at Hard Rock Bet as the Rays look to close out the ALCS and advance to the World Series for the first time since 2020:

• The Rays are drawing most of the support on the moneyline with 77% of wagers and 89% of the handle.
• The run line action leans heavily in Tampa Bay’s favor, with the Rays accounting for 95% of wagers and 98% of the handle.
• The Over is attracting the majority of action on the total with 73% of wagers and 96% of the handle.

Guardians vs. Rays Game Info

• 📍 Where: Tropicana Field, St. Petersburg, FL
• 📅 Date: Monday, Oct. 19
• ⏰ First Pitch: 8:00 PM ET
• 📺💻 TV/Streaming: TBS, truTV
• ⚾ Probable Pitchers:
  • Guardians: Shawn Armstrong
  • Rays: Freddy Peralta
• 🏆 Stage: ALCS – Game 6

More Ways to Bet

One swing can cash your ticket, but until then, Florida players can keep things interesting with Real Money Games powered by Past Motor Racing, only on Hard Rock Bet. It’s another way to stay engaged between plate appearances.

Referenced odds are subject to change.