No. 20 Oregon vs. No. 12 USC Predictions, Picks & Odds for Week 4

The No. 20 Oregon Ducks (2-1, 0-0 Big Ten) head to Southern California to take on the No. 12 USC Trojans (4-0, 1-0 Big Ten) for a Week 4 college football clash at the Los Angeles Memorial Coliseum on Saturday. This will be Oregon’s Big Ten opener, while USC has already begun its conference schedule after beating Rutgers 42-35 last Saturday.

Last week’s game was much closer than Lincoln Riley and USC would’ve liked against Rutgers, but the Trojans managed to escape Piscataway with a road win to improve to 4-0, which, at the end of the day, is all that matters. USC totaled 461 yards of offense, with quarterback Jayden Maiava throwing two touchdown passes and running back King Miller leading the team with 102 rushing yards.

The game was so close against Rutgers because the Trojans’ defense allowed 460 yards of total offense. That has unfortunately become a common theme for USC so far this season, as the Trojans have already allowed 358 yards of offense to Louisiana in Week 2 and 336 total yards to San José State in Week 0.

After a tough loss to eventual national champion Indiana in the College Football Playoff semifinals last season, Oregon had a bit of a shaky start to this season. The Ducks won a close one, 34-27, against Boise State in Week 1 but then suffered a 39-31 loss to Oklahoma State in Week 2.

However, Dan Lanning’s squad bounced back with a dominant 84-0 shutout last Friday against Portland State, with the Ducks’ offense totaling 740 yards while the defense held its opponent to just 103 total yards, including only two rushing yards. Quarterbacks Dante Moore and Dylan Raiola combined to throw seven touchdown passes, with backup Raiola completing all 11 of his pass attempts.

Continue on for Oregon vs. USC predictions, picks, and odds ahead of Saturday’s Week 4 matchup at the Coliseum.

Oregon vs. USC Odds

Hard Rock Bet Sportsbook lists Oregon as a road favorite for Saturday’s matchup:

• Moneyline: Oregon -165, USC +135
• Spread: Oregon -2.5 (-125), USC +2.5 (+105)
• Total: Over 61.5 Points (-110), Under 61.5 Points (-110)

Oregon vs. USC Predictions

Don’t miss the chance to get in on Saturday’s ranked Big Ten West Coast matchup, with Hard Rock Bet Sportsbook offering a wide range of football betting markets and plenty of ways to make wagers on the game, like our Oregon vs. USC prediction below:

USC vs. Oregon Best Bet: Over 61.5 Points (-110)

It’s no secret that both of these offenses can put up points on any given week. Oregon just scored a ridiculous 84 points last week and is averaging nearly 50 points per game this season, while USC is averaging 43 points per game. If that alone doesn’t provide enough insight to support this pick, then keep reading.

Both offenses can clearly find the end zone often, but the defenses also play a role in this. There have been some good moments for both defenses this season, but the two units have also allowed quite a few yards, points, and overall offensive success.

Oregon allowed 58 points through its first two games before its 84-0 shutout against Portland State, while USC is allowing 22.75 points per game this season. It’s hard not to expect a lot of offense at the Coliseum on Saturday.

• USC vs. Oregon Total Pick for Sept. 26: Over 61.5 Points (-110)

Oregon vs. USC Betting Splits

Here’s how the action is trending at Hard Rock Bet for Oregon vs. USC:

• Oregon is getting more moneyline support, with 54.82% of bets and 76.39% of the handle.
• USC is drawing slightly more action on the spread, with 51.79% of bets, but the Ducks account for 60.96% of the handle.
• The Over is receiving the majority of action on the total, with 84.99% of bets and 92.85% of the handle.

Oregon vs. USC Game Info

• 📍 Where: Los Angeles Memorial Coliseum, Los Angeles, CA
• 📅 Date: Saturday, Sept. 26
• ⏰ Kickoff: 7:30 PM ET
• 📺💻 TV/Streaming: NBC

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