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The No. 17 Iowa Hawkeyes (3-0, 0-0 Big Ten) head to Ann Arbor, Michigan, to take on the No. 18 Michigan Wolverines (3-0, 0-0 Big Ten) as both teams open conference play in a massive Week 4 college football matchup with a 3:30 p.m. ET kickoff Saturday afternoon.

Michigan has had an interesting start to the season, to say the least, after escaping with a controversial 13-12 Week 1 win over Western Michigan, followed by a low-scoring 17-10 victory against then-No. 11 Oklahoma despite the Sooners making things close in the second half.

Things weren’t necessarily pretty for Michigan through the first two weeks, and after a somewhat tough first half against UTEP last Saturday in which the Wolverines turned the ball over twice and took just a 17-14 lead into halftime, they blew things open in the second half. Michigan scored 28 third-quarter points en route to a 52-17 win to improve to 3-0.

Iowa opened its season with a 40-0 shutout win over Northern Illinois but then found itself in a tight matchup against Iowa State in Week 2 that the Hawkeyes managed to squeak out a 16-13 win. Iowa then had another dominant performance last Saturday with a 55-0 shutout victory against Northern Iowa to secure its second shutout of the season.

Iowa compiled 640 total yards of offense against Northern Iowa, including a whopping 422 rushing yards. Running backs Nathan McNeil, Braeden Jackson, and Xavier Williams each rushed for over 100 yards in the win, with Williams leading the way with 151 rushing yards, three rushing touchdowns, and an astonishing 25.2 yards per carry. The trio combined for six rushing touchdowns, and Jackson also caught a 24-yard touchdown pass.

Looking for Iowa vs. Michigan predictions, picks, and odds? We’ve got you covered below ahead of Saturday’s ranked Big Ten matchup.

Iowa vs. Michigan Odds

Michigan is listed as the home favorite at Hard Rock Bet Sportsbook for Saturday’s Big Ten showdown:

  • Moneyline: Michigan -225, Iowa +175
  • Spread: Michigan -5.5 (-110), Iowa +5.5 (-110)
  • Total: Over 38.5 Points (-110), Under 38.5 Points (-110)
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Iowa vs. Michigan Predictions

Hard Rock Bet Sportsbook offers plenty of ways to get in on the football betting action, including making wagers like our Iowa vs. Michigan prediction below as these two ranked teams battle to keep their undefeated seasons alive:

Michigan vs. Iowa Best Bet: Iowa +5.5 (-110)

Michigan hasn’t seemed to put it all together yet this season, particularly on offense, so that could lead to some issues Saturday against an Iowa defense that already has two shutouts in three games. The Hawkeyes’ defense is allowing roughly 176.7 total yards per game this season and has allowed just 13 points while also forcing four turnovers.

Michigan’s defense has also been a bright spot for the most part, but the Wolverines did allow 100 or more rushing yards in two of their first three games. Remember, Iowa rushed for 422 yards in Week 3, with three different running backs recording over 100 rushing yards.

It could be a defensive game that makes the total intriguing, but it should also be a game that Iowa could go into the Big House and win or, at the very least, keep within five points in a loss.

  • Michigan vs. Iowa Spread Pick for Sept. 26: Iowa +5.5 (-110)

Iowa vs. Michigan Betting Splits

Here’s how the action is trending at Hard Rock Bet for Saturday’s game at the Big House:

  • Michigan is generating 56.27% of wagers on the moneyline, but Iowa is attracting more dollars at 56.32%.
  • The Hawkeyes are drawing more support on the spread, with 74.19% of wagers and 54.03% of dollars.
  • The total is seeing more action on the Over, with 61.36% of wagers and 64.02% of dollars.

Iowa vs. Michigan Game Info

  • šŸ“ Where: Michigan Stadium, Ann Arbor, MI
  • šŸ“… Date: Saturday, Sept. 26
  • ā° Kickoff: 3:30 PM ET
  • šŸ“ŗšŸ’» TV/Streaming: CBS

More Ways to Bet

Looking for more ways to stay in the action? Florida players can find Real Money Games powered by Past Motor Racing, available exclusively on Hard Rock Bet, a lineup of fast, engaging real money games you can jump into anytime while you follow your bets.

Referenced odds are subject to change.

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Michael Hennelly

Michael has been an active sports contributor for multiple publications since graduating from Penn State in 2024. While sports play a major role in his life (in the best way), he also enjoys spending time with family and friends. Contact Michael at michael.hennelly at hardrockdigital.com.