The 2026 Campeones Cup is here, with defending MLS Cup champion Inter Miami taking on Liga MX’s Clausura 2026 champion and Campeón de Campeones winner Cruz Azul on Wednesday night at Nu Stadium in South Florida.
Inter Miami secured its first-ever MLS Cup with a win over the Vancouver Whitecaps back in December to earn its place in the Campeones Cup. Rodrigo De Paul scored the go-ahead goal in the 71st minute before Tadeo Allende sealed the victory with a goal in the sixth minute of stoppage time to help deliver Inter Miami its first MLS Cup title. Both goals were assisted by the legendary Lionel Messi.
More recently, Inter Miami (12-9-4) sits second in the MLS Eastern Conference standings, with each of its previous three matches ending in draws. Messi continues to defy age, as his 19 goals this season lead both Inter Miami and all MLS players.
Cruz Azul earned its place in the Campeones Cup by defeating Pumas UNAM 2-1 on aggregate to claim the Clausura 2026 title in May before beating Toluca 3-1 in the Campeón de Campeones in July. Cruz Azul (5-0-3) currently sits fourth in Liga MX with 15 points and enters Wednesday in strong form after winning each of its last three matches.
Read below for our Inter Miami vs. Cruz Azul predictions, picks, betting splits, and more for the 2026 Campeones Cup.
Inter Miami vs. Cruz Azul Odds
Hard Rock Bet Sportsbook lists Inter Miami as the favorite for the 2026 Campeones Cup as it plays in its home stadium Wednesday night.
- Inter Miami: -105
- Cruz Azul: +240
- Draw: +275
Inter Miami vs. Cruz Azul Predictions for 2026 Campeones Cup
Hard Rock Bet Sportsbook offers a variety of soccer betting markets for the 2026 Campeones Cup, so make sure to check them out and get in on the action with wagers like our Inter Miami vs. Cruz Azul prediction below:
Cruz Azul vs. Inter Miami Best Bet: Inter Miami (-105)
Cruz Azul enters in excellent form and has history on its side, with Liga MX teams owning a 4-3 record against MLS teams in the Campeones Cup, including victories in each of the previous three editions. Cruz Azul also played in the 2021 Campeones Cup, losing 2-0 to the Columbus Crew. This will be Inter Miami’s debut in the competition, but Cruz Azul’s experience from five years ago doesn’t necessarily provide much of an advantage Wednesday night.
Inter Miami features a star-studded roster with the likes of Lionel Messi, Luis Suárez, Rodrigo De Paul, and Casemiro, making it a formidable opponent in any competition. There’s also a notable storyline to follow, as Messi enters Wednesday night with 99 goals in his Inter Miami career and could reach or even surpass the century mark against Cruz Azul.
It’s also worth monitoring Cristian “Kily” González as he makes his debut as Inter Miami’s head coach in Wednesday night’s Campeones Cup, taking over for interim coach Guillermo Hoyos. Coaching changes can sometimes impact the product on the field, whether positively or negatively, but Inter Miami has enough talent that it shouldn’t be too much of a concern.
- Cruz Azul vs. Inter Miami Three-Way Moneyline Pick for Sept. 16: Inter Miami (-105)
Popular Props for Inter Miami vs. Cruz Azul
Messi is unsurprisingly one of the most popular selections in the player prop markets heading into kickoff:
- Lionel Messi – Anytime Goalscorer
- Lionel Messi – To Score 2+ Goals
- Lionel Messi – First Goalscorer
Inter Miami vs. Cruz Azul Betting Splits
Here’s how the action on the three-way moneyline is trending at Hard Rock Bet for the 2026 Campeones Cup between Inter Miami and Cruz Azul:
- Inter Miami is drawing 91.5% of bets and 84.9% of the handle.
- Cruz Azul is generating much less support with 7.6% of bets and 13.2% of the handle.
- The draw accounts for just 0.9% of bets and 1.9% of the handle.
Inter Miami vs. Cruz Azul Match Info
- 📍 Location: Nu Stadium, Miami, FL
- 📅 Date: Wednesday, Sept. 16
- ⏰ Start Time: 8:00 PM ET
- 📺 Where to Watch: Apple TV
- 🏆 Stage: 2026 Campeones Cup
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Referenced odds are subject to change.
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