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Inter Miami begins its 2026 Leagues Cup schedule Wednesday night when it welcomes Atlético San Luis to South Florida. The opening match for both sides is scheduled to kick off at 7:30 p.m. ET from Nu Stadium, where the Herons will play each of their first three Leagues Cup contests.

The competition holds plenty of significance for Inter Miami. Lionel Messi made his club debut during the 2023 Leagues Cup, coming off the bench against Cruz Azul and scoring a memorable stoppage-time free kick to secure a 2-1 victory. Miami eventually defeated Nashville in a penalty shootout to capture the first trophy in club history.

Inter Miami returned to the final last season but suffered a 3-0 defeat against the Seattle Sounders. The aftermath of that match continues to impact Inter Miami, as Luis Suárez is currently serving a six-game Leagues Cup suspension and will miss the entire 2026 tournament after spitting at a Sounders staff member following the loss. His absence leaves a major hole in Miami’s attack after the Uruguayan scored seven goals across his previous four appearances.

Inter Miami could also be without Germán Berterame, who remains in concussion protocol after sustaining a head injury against CF Montréal and is unlikely to suit up against his former club. With Berterame’s status in doubt and Suárez unavailable, Messi is expected to take on an even larger role in Miami’s attack against Atlético San Luis.

Inter Miami vs. Atlético San Luis Odds

Here are the latest 3-way moneyline odds available at Hard Rock Bet Sportsbook:

  • Inter Miami (-275)
  • Draw (+425)
  • Atlético San Luis (+575)

Is Messi Playing Tonight?

Lionel Messi is expected to play for Inter Miami in Wednesday night’s Leagues Cup opener against Atlético San Luis.

Messi returned to club action over the weekend and should be available as Inter Miami begins another pursuit of the Leagues Cup trophy. His presence becomes even more important with Suárez suspended and Berterame unlikely to play.

Betting Splits at Hard Rock Bet

Hard Rock Bet players have shown overwhelming support for the home side ahead of Wednesday night’s matchup:

  • Inter Miami is receiving 95.8% of all moneyline tickets and 97.6% of the handle.
  • Atlético San Luis has attracted just 0.9% of all bets and 1.2% of the money wagered.
  • Draw is receiving the smallest share of the action, accounting for 0.3% of tickets and 0.2% of the handle.

Top 5 Most-Bet Player Props

With Inter Miami down a few key players on offense, Hard Rock Bet players are all over Messi props:

  1. Lionel Messi – Over 1.5 Shots on Target
  2. Lionel Messi – Anytime Goalscorer
  3. Lionel Messi – To Score or Assist
  4. Casemiro – To Record an Assist
  5. Santiago Muñoz – Anytime Goalscorer

Inter Miami vs. Atlético San Luis Match Info

  • 📍 Location: Nu Stadium, Miami, Florida
  • 📅 Date: Wednesday, August 5
  • ⏰ Start Time: 7:30 p.m. ET
  • 📺 Where to Watch: Apple TV

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Michael Sciangula

Michael Sciangula is a New Jersey-based sports betting and online casino writer. He has contributed iGaming content to several publications over the last half decade including the Action Network, New York Post and Philadelphia Inquirer. Contact Michael at [email protected].