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The Cleveland Cavaliers are on the verge of their first Eastern Conference Finals appearance since the 2017-18 NBA season. After three consecutive wins against the No. 1-seeded Detroit Pistons, including a 117-113 overtime thriller in Game 5, Cleveland now has the chance to advance in front of its home fans Friday night in Ohio.

The Pistons actually led for the majority of Game 5, but thanks to a 32-point third quarter in which Cleveland outscored Detroit by 12, the Cavaliers managed to get back into the game and take control late. Even after Cleveland’s comeback, the Pistons still held a nine-point lead with three minutes remaining in the fourth quarter but were unable to close the game out.

Problems arose for Detroit late in the game as All-Star center Jalen Duren was benched in the fourth quarter and overtime due to his ongoing playoff struggles. Veteran forward Tobias Harris was also a non-factor in the game’s crucial moments, shooting just 1-for-6 between the fourth quarter and overtime.

It’s been a battle all postseason long for the Pistons, but now their season comes down to Friday night, as a Cavaliers win would eliminate Detroit from the playoffs.

Pistons vs. Cavaliers Game 6 Odds

The Cavaliers are listed as home favorites for Game 6 at Hard Rock Bet Sportsbook:

  • Moneyline: Cavaliers -170, Pistons +145
  • Spread: Cavaliers -4.5 (-105), Pistons +4.5 (-115)
  • Total: Over 210.5 points (-110), Under 210.5 points (-110)

With the chance to advance at home, the Cavaliers have -325 odds to win the series and move on to face the New York Knicks in the Eastern Conference Finals.

Pistons vs. Cavaliers Picks & Predictions for Game 6

The Stats Hub at Hard Rock Bet Sportsbook offers unique betting insights for Pistons vs. Cavaliers Game 6 and many other markets, so sign up today to use it to your advantage. Below are two picks for Friday night’s matchup that can be found there:

Pistons vs. Cavaliers Best Bet: James Harden Over 6.5 Assists

James Harden has been one of the greatest playmakers of his generation, and he’s still making things happen at 36 years old. Not only is Harden a three-time scoring champion, but he also ranks 12th all-time in assists and currently sits third among active players behind only Russell Westbrook and LeBron James.

Harden averaged eight assists per game between the Los Angeles Clippers and Cavaliers during the regular season, and the veteran is averaging a respectable 6.4 assists per contest through 12 playoff games. He’s gone over 6.5 assists in three of his last five games and in half of his playoff appearances this postseason.

  • Pistons vs. Cavaliers Game 6 Player Prop Pick: James Harden Over 6.5 Assists (-115)

James Harden May 15 Stats Hub Assists

Pistons vs. Cavaliers Best Bet: Dean Wade Over 3.5 Rebounds

Dean Wade averaged 4.2 rebounds per game during the regular season and has maintained that same average during the playoffs. The Cavaliers forward has gone over 3.5 rebounds in each of his last two games and in three of his last five.

Wade should have plenty of opportunities to grab four or more rebounds in Game 6, as he’s averaging 23.8 minutes per game this postseason, making this plus-money prop worth considering.

  • Pistons vs. Cavaliers Game 6 Player Prop Pick: Dean Wade Over 3.5 Rebounds (+105)

Dean Wade May 15 Stats Hub Rebounds

Top 5 Most-Bet Player Props for DET-CLE

Cade Cunningham leads both the Pistons and all playoff scorers with 30 points per game, and he’ll likely need another huge scoring performance to keep Detroit’s season alive and force a Game 7. Check out the five most-bet player props, including alternate lines, for Friday’s Pistons vs. Cavaliers Game 6:

  1. Cade Cunningham Over 24.5 Points
  2. James Harden Over 19.5 Points
  3. James Harden Over 14.5 Points 
  4. Donovan Mitchell Over 19.5 Points
  5. Cade Cunningham Over 19.5 Points

Pistons vs. Cavaliers Game 6 Info

  • 📍 Where: Rocket Arena, Cleveland, OH
  • 📅 Date: Friday, May 15
  • Start Time: 7:00 PM ET
  • 📺💻 TV/Streaming: Prime Video
  • 🏀 Series: 3-2 Cavaliers

Pistons-Cavaliers Key Injuries & Availability

With either the Cavaliers advancing or the Pistons forcing a Game 7 on the line Friday night, expect players to battle through injuries to suit up. However, anything can happen leading up to tip-off, so be sure to monitor each team’s status for any late changes that could impact basketball betting markets.

Pistons Injury Report

  • Caris LeVert: QUESTIONABLE (heel)
  • Duncan Robinson: QUESTIONABLE (back)
  • Kevin Huerter: QUESTIONABLE (adductor)

Cavaliers Injury Report

  • N/A

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Referenced odds are subject to change.

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Michael Hennelly

Michael has been an active sports contributor for multiple publications since graduating from Penn State in 2024. While sports play a major in his life (in the best way), he also enjoys spending time with family and friends. Contact Michael at [email protected].