The Milwaukee Brewers (23-16) host the San Diego Padres (24-17) for Game 2 of a three-game series at American Family Field between two of the National League’s top teams.
The Brewers enter on a five-game winning streak after Tuesday’s 6-4 victory in the series opener. Wednesday night features a marquee pitching matchup between veteran Michael King of the Padres and young flamethrower Jacob Misiorowski of the Brewers.
Both teams enter Wednesday with nearly identical records while competing in tough divisions. The Brewers sit in second place in the NL Central, where all five teams are above .500, while the Padres lead the NL West by a half-game over the defending back-to-back World Series champion Los Angeles Dodgers.
Padres vs. Brewers Current Odds
The Brewers enter Game 2 as the hotter team and will have standout starter Jacob Misiorowski on the mound, leading Hard Rock Bet Sportsbook to list Milwaukee as the home favorite:
- Moneyline: Brewers -150, Padres +125
- Run Line: Brewers -1.5 (+140), Padres +1.5 (-195)
- Total (Runs): Over 6.5 (-135), Under 6.5 (+110)
Padres vs. Brewers Picks & Predictions for May 13
Looking for more informed MLB wagers? Check out the Stats Hub at Hard Rock Bet Sportsbook to track recent player and team trends before placing your bets.
If Hard Rock Bet is available in your state, sign up today to access the Stats Hub and explore deeper betting insights. Here are two featured picks for Wednesday night’s matchup:
Padres vs. Brewers Best Bet: Jacob Misiorowski Over 7.5 Strikeouts
With all the buzz surrounding Jacob Misiorowski, it would feel wrong not to include him here. The Brewers’ starter is coming off another dominant outing and enters Wednesday leading MLB in strikeouts.
While the prop isn’t plus money, Misiorowski has recorded over 7.5 strikeouts in each of his last four starts and in six of his eight outings this season.
- Padres vs. Brewers Player Prop Pick for May 13: Jacob Misiorowski Over 7.5 Strikeouts (-150)
Padres vs. Brewers Best Bet: Manny Machado Over 0.5 Hits
Manny Machado hasn’t had the offensive start he hoped for, entering Wednesday with a .193 batting average, but he has consistently hit at American Family Field. The seven-time All-Star owns a 10-game hitting streak at Milwaukee’s home ballpark, including a hit in Tuesday’s series opener.
Although it’s not a plus-money play, Machado has a strong chance to extend that streak to 11 games Wednesday night.
- Padres vs. Brewers Player Prop Pick for May 13: Manny Machado Over 0.5 Hits (-150)
Top 5 Most-Bet Player Props for SD-MIL
Jacob Misiorowski headlines Wednesday’s pitching matchup, but offense is driving most of the baseball betting action heading into first pitch:
- Brice Turang – Hits Over 0.5
- Fernando Tatís Jr. – Home Runs Over 0.5
- William Contreras – Hits Over 0.5
- Fernando Tatís Jr. – Hits Over 0.5
- Jacob Misiorowski – Strikeouts Over 7.5
Padres vs. Brewers Pitching Matchup: King vs. Misiorowski
Michael King returned to the Padres after signing a three-year, $75 million contract in December. The right-hander finished seventh in NL Cy Young voting in 2024 during his first season in San Diego after spending the first five years of his career with the New York Yankees, but injuries limited him to just 15 regular-season starts in 2025.
King has bounced back nicely in 2026, posting a 2.76 ERA with 45 strikeouts across 45.2 innings through his first eight starts. He tossed six strong innings of one-run, one-hit baseball in his last outing against St. Louis and will look to build on that performance Wednesday night.
After earning All-Star honors and finishing 11th in NL Rookie of the Year voting last season, Jacob Misiorowski has been dominant to begin his sophomore campaign. The 24-year-old is 3-2 with a 2.45 ERA, a 0.955 WHIP, and an MLB-leading 70 strikeouts through eight starts.
Misiorowski isn’t just piling up strikeouts, he’s throwing elite velocity. The right-hander hit 103.6 mph three times in his last outing against the Yankees, the highest velocity recorded by a starting pitcher since Statcast tracking began in 2008. He struck out 11 batters across six shutout innings in that performance.
If you’re a fan of pitching, Wednesday night’s Padres vs. Brewers matchup is must-watch baseball.
Padres vs. Brewers Game Info
- 📍 Where: American Family Field, Milwaukee, WI
- 📅 Date: Wednesday, May 13
- ⏰ First Pitch: 7:40 PM ET
- 📺💻 TV/Streaming: MLB.TV
- ⚾ Probable Pitchers:
- Padres: Michael King
- Brewers: Jacob Misiorowski
More Ways to Bet
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Referenced odds are subject to change.
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