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I’ve got a lot of college football picks for you for Week 3. I’m on the over in the Miami-Wake Forest game, which is a Friday game.

And, like I said, my Blood Bank is Indiana -44.5 and the over. Let’s get to the analysis:

Clay Travis’ College Football Picks – Week 3

Here’s the Week 3 card in full:

  • Miami vs. Wake Forest – OVER 55.5 (Thursday)
  • North Carolina vs.  Clemson – UNDER 43.5
  • NC State vs. Vanderbilt – OVER 50.5
  • UTEP +35.5 vs. Michigan
  • Kentucky vs. Texas A&M – OVER 49.5
  • SMU vs. Louisville – OVER 59.5
  • Purdue vs. UCLA – OVER 52.5
  • Indiana -44.5 vs. Western Kentucky
  • Western Kentucky vs. Indiana – OVER 59.5 (Blood Bank🩸)
  • Mississippi State +3.5 vs. South Carolina
  • Florida vs. Auburn – UNDER 53.5
  • Virginia Tech -2.5 vs. Maryland
  • Notre Dame -29.5 vs. Michigan State
  • LSU -3 at Ole Miss
  • LSU vs. Ole Miss – OVER 58.5
  • Alabama -19.5 vs. Florida State

Clay Travis Week 3 College Football Picks 2026

LSU (-3) at Ole Miss

I would bet, and I already have bet, on LSU in this game and the over against Ole Miss.

Why? I think that Lane Kiffin knows this Ole Miss roster really well. I believe that he knows their weaknesses. I think he will be able to attack them in a particularly successful way, which is why I’m taking LSU.

I got them at -3. They’re now -2.5, which was the most recent number that I have seen. I think that, again, a lot of these players that are being listed on the injury report will all play and look like they are fine.

I’m taking the over in this game as well.

Alabama (-19.5) vs. Florida State

I love Alabama to blow out Florida State. That’s it.

Indiana (-44.5) vs. Western Kentucky – Blood Bank Pick 🩸

I believe that we are going to see a total blowout from Indiana.

This is a big number. I think they’re going to cover the 44.5 point spread against Western Kentucky and the over is going to hit in that game.

Western Kentucky just gave up 70 to Georgia last week. They gave up 49, I believe it was, to Nevada. They can’t stop anybody. And we know that Cignetti has not exactly been shown to show a great deal of mercy when it comes to not running up the score.

So, my double Blood Bank pick for college football is in the same game: Indiana -44.5 and the over in that game.

All referenced odds are subject to change.

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Clay Travis

Clay Travis is an author, broadcaster, and media commentator best known as the founder of OutKick, the sports and culture site he built from scratch in 2011 and grew into one of the most influential digital platforms in sports media before it was folded into Fox News Digital fifteen years later. Born in 1979, Travis is a graduate of George Washington University and Vanderbilt University Law School, and worked as a lawyer before turning to sports media full-time. He now serves as a Fox News Media contributor and continues to host OutKick the Show with Clay Travis on FS1, in addition to co-hosting The Clay Travis and Buck Sexton Show. Known for a blend of sharp analysis, humor, and outspoken commentary on sports, politics, and culture, Travis has built a reputation as one of the most-heard voices in American media, reaching millions of listeners and readers across radio, television, and digital platforms. His writing and commentary range from college football to the business of sports to the intersection of sports and politics, and he's never shied away from a contrarian take.