Astros vs. Cubs Odds, Splits, Picks & Predictions for Matinee at Wrigley Field

Two clubs searching for answers open a three-game interleague series at Wrigley Field on Friday afternoon. The Houston Astros (20-31) sit in last place in the AL West and have managed to score just five runs in their last four games. The Chicago Cubs (29-21), meanwhile, enter this matchup on a five-game losing streak after getting swept at home by Milwaukee, dropping them 1.5 games behind the Brewers in the NL Central.

The most intriguing angle for this afternoon is on the mound. Spencer Arrighetti (5-1, 1.50 ERA) has pitched like an ace all year on a team that can’t seem to get it right, while Jameson Taillon (2-3, 4.97 ERA) has struggled overall but has a track record of pitching well at Wrigley Field, boasting a 3.28 ERA at home since joining the Cubs in 2023.

Here’s a look at the odds, the most popular player props at Hard Rock Bet, and a Stats Hub pick for this matinee in the Windy City.

Astros vs. Cubs Odds

Despite Chicago’s recent struggles and Houston having the pitching advantage, the Cubs jump out as moderate home favorites:

• Moneyline: Astros +120 / Cubs -145
• Run Line: Astros +1.5 (-185) / Cubs -1.5 (+150)
• Total: Over 7.5 (+115) / Under 7.5 (-135)

Best Bet for Astros vs. Cubs

Here’s our top pick for this afternoon’s series opener, courtesy of Hard Rock Bet’s Stats Hub. Open the app and tap ‘Stats Hub’ at the top of your homepage to explore streaks, matchup data, and betting trends for every game on the board. Don’t have an account yet? Sign up with Hard Rock Bet Sportsbook today – click here to get started.

Ian Happ Under 0.5 Hits (-115): Happ’s bat has gone completely cold as of late. He’s hitless in his last 21 at-bats dating back to May 15, and he hasn’t recorded a hit in any of his last five games. Zooming out further, Happ has gone without a hit in 13 of 19 games in May and is hitting just .188 during that stretch. This afternoon he faces Arrighetti, who has surrendered only four hits across his last 12.1 innings. Chillier Wrigley Field conditions only strengthen the case, with temperatures hovering around the 60s at first pitch.

Astros vs. Cubs Betting Splits

Here’s how players at Hard Rock Bet are lining up on this one:

• Moneyline: The Cubs are attracting roughly 70% of all tickets to go along with 64% of the handle.
• Run Line: About 54% of all bets favor the Cubs -1.5, but Chicago is absorbing around 88% of the money.
• Total: Approximately 62% of all bets sit on the Over 7.5, even though the Under has cashed in six consecutive Cubs games.
• NRFI: Close to 73% of the first inning action is backing No Run First Inning.

Top 5 Most-Bet Player Props

1. Yordan Alvarez – Over 0.5 Home Runs
2. Nico Hoerner – Over 0.5 Hits
3. Yordan Alvarez – Over 0.5 Hits
4. Jeremy Peña – Over 0.5 Hits
5. Alex Bregman – Over 0.5 Hits

Astros vs. Cubs Game Info

• 📍 Where: Wrigley Field, Chicago, IL
• 📅 Date: Friday, May 22
• ⏰ Start Time: 2:20 PM ET
• 📺💻 TV/Streaming: Apple TV

Referenced odds are subject to change.

More ways to bet

Watching the game is just part of the experience. With Real Money Games powered by Past Motor Racing, available exclusively on Hard Rock Bet, Florida players have another way to stay in the action with quick, exciting gameplay throughout.