49ers vs. Chargers Odds & Betting Splits for West Coast Preseason Action

The Los Angeles Chargers (1-0) host the San Francisco 49ers (0-1) in a West Coast matchup to conclude Thursday’s two-game NFL preseason slate.

Both teams are expected to give some of their starters playing time to begin the game, including quarterbacks Brock Purdy and Justin Herbert, although, as you’d expect in the preseason, those players won’t remain on the field for too long.

A few storylines to follow in this matchup involve the offensive line, as both teams are doing some shuffling due to injuries or holes atop the depth chart. Meanwhile, 49ers second-round rookie wide receiver De’Zhaun Stribling continues to generate plenty of hype after a standout offseason to this point. He also had a stellar preseason debut in Week 1, catching seven passes for 63 yards, including a 32-yard reception against Tennessee.

49ers vs. Chargers Odds

While football betting markets are more limited during the preseason, Hard Rock Bet Sportsbook still offers several options and lists the 49ers as road favorites for Thursday night’s matchup:

• Moneyline: 49ers -120, Chargers +100
• Spread: 49ers -1.5 (+100), Chargers +1.5 (-120)
• Total: Over 37.5 Points (-115), Under 37.5 Points (-105)

49ers vs. Chargers Betting Splits

Here’s how the action is trending at Hard Rock Bet for Thursday night’s 49ers vs. Chargers West Coast preseason matchup at SoFi Stadium:

• The Chargers are drawing more support on the moneyline with 64.7% of bets and 62.8% of the handle.
• Los Angeles is attracting the majority of the action on the spread with 77.4% of bets and 88.2% of the handle.
• The Under is the favorite on the total, accounting for 54% of bets and 60.7% of the handle.

49ers vs. Chargers Game Info

• 📍 Where: SoFi Stadium, Inglewood, CA
• 📅 Date: Thursday, Aug. 20
• ⏰ Kickoff: 10:00 PM ET
• 📺💻 TV/Streaming: NFL Network