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Thursday afternoon’s NCAA Tournament slate features a matchup with strong Florida ties, as No. 11 South Florida squares off against No. 6 Louisville in the East Region at KeyBank Center in Buffalo.

Tip-off is set for 1:30 PM ET on TNT. South Florida will look to keep its impressive season going on the national stage, while Louisville aims to prevent an early upset and advance. The winner moves on to face either No. 3 Michigan State or No. 14 North Dakota State in the second round.

For fans in Florida, this is a chance to see USF represent on a national stage, and potentially deliver one of the early surprises of the tournament.

South Florida enters at 25-8, putting together one of the more notable seasons among double-digit seeds, while Louisville brings a 23-10 record into tournament play.

South Florida vs. Louisville Game Info

  • 📍 Where: KeyBank Center, Buffalo, New York
  • 📅 Date: Thursday, March 19
  • Start Time: 1:30 PM ET
  • 📺💻 TV/Streaming: TNT

South Florida vs. Louisville Odds at Hard Rock Bet

As of Thursday morning, Louisville is favored at Hard Rock Bet Sportsbook, though USF is well within striking distance.

Market
Odds
MoneylineLouisville -190, South Florida +150
Point SpreadLouisville -4.5 (-105), South Florida +4.5 (-115)
Total (Over/Under)Over 163.5 (-110), Under 163.5 (-110)

With Louisville favored by more than a single possession, the pressure will be on the Cardinals to control the game early. For South Florida, the path to an upset likely involves staying efficient offensively and limiting second-chance opportunities.

South Florida vs. Louisville Betting Splits

Here’s how players at Hard Rock Bet are wagering on this afternoon’s matchup:

  • Louisville is drawing more moneyline support with 56.4% of tickets, but the larger wagers are backing South Florida, which accounts for 69.9% of the handle.
  • South Florida is seeing overwhelming support against the spread, capturing 79.2% of tickets and an even stronger 87.4% of the handle compared to Louisville.
  • While the bet count and handle are nearly split for the total, the Under holds the edge with 54.3% of tickets and 51.5% of the handle, indicating a slight lean toward a lower-scoring game.

Referenced odds are subject to change.

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Michael Hennelly

Michael has been an active sports contributor for multiple publications since graduating from Penn State in 2024. While sports play a major in his life (in the best way), he also enjoys spending time with family and friends. Contact Michael at [email protected].