BettingPros Best Bets for NFL Week 10

NFL Week 10 is here, and the BettingPros squad is back with another round of best bets.

 

Panthers -5.5 vs Saints

Betting against rookie quarterbacks on the road remains one of the most profitable angles in football, and this week’s victim is Tyler Shough. Carolina hosts New Orleans with momentum and matchup edges on both sides of the ball.

The Saints’ offense is broken: banged-up line, traded some weapons, and a rookie QB making back-to-back road starts. That’s a disaster setup against a Panthers defense ranking sixth in red-zone efficiency. Carolina, meanwhile, has quietly gone 3-1 ATS at home and is pounding the ball behind Rico Dowdle and a surging ground game.

The Saints have lost 13 straight as underdogs. The Panthers keep that streak alive and keep pounding in Charlotte.

Bears Team Total Over 25.5 vs Giants

Chicago’s offense at home has been electric, averaging 27 points per game and clearing 24+ in every appearance at Soldier Field this season. Caleb Williams has thrived in front of the home crowd, and his supporting cast is finally clicking.

The Giants’ defense has allowed over 31 points per game on the road, and their secondary remains one of the most banged-up units in football. Even with an improving pass rush, they’ve been shredded by explosive plays and poor tackling on the back end.

Whether it’s Monangai pounding inside or Swift flashing outside, the Bears’ offense should roll again. Don’t overthink it – trust the trend and back the home fireworks.

Patriots +3 at Buccaneers

Road dogs travel well, and this version of New England fits that mold. The Patriots have covered five straight on the road and continue to grind games into their preferred low-possession style.

Tampa Bay, on the other hand, has been unreliable as a home favorite: just 5-8 ATS in that spot since 2023. The Bucs’ offense is depleted with Mike Evans out and Chris Godwin questionable, leaving Baker Mayfield short on weapons. Meanwhile, Christian Gonzalez’s return gives the Patriots a chance to slow down the Bucs’ lone deep threat in Egbuka.

Take the points, take the pedigree, and take the Pats to keep it within a field goal – or better.

Rams at 49ers: Under 49.5

Unders dominate in this rivalry, and it’s no mystery why. Both teams rank top-10 in red-zone defense, and nine of their last twelve meetings have finished below the total.

The Rams’ defense leads the league in red-zone scoring prevention, while San Francisco – despite injuries – remains fundamentally sound. The 49ers’ home games against NFC West opponents have all stayed under, and the earlier season matchup between these two only broke 49 points after overtime.

Expect a measured, field-goal-heavy affair in a divisional war that rarely turns into a shootout.

🎸 Hard Rock Best Bets of the Week

Now it’s time for our Hard Rock Best Bets of the Week:

Cardinals at Seahawks: Under 45.5

The “Lasso Lag” strikes again. Teams following a game against Dallas typically struggle to move the ball.

Dalton Schultz Over 3.5 Receptions (-145)

Schultz has topped this mark in five of his last eight games, and Jacksonville has allowed the fourth-most catches to tight ends over the past month. Reliable, high-floor volume play.

Upset Special: Eagles (+116 ML) at Packers

Philadelphia has won both meetings against Green Bay in the Jordan Love era and just reloaded its secondary with fresh reinforcements. Green Bay’s home mystique fades as the Birds fly into Lambeau and flip the script.

Parlay of the Week (+316):

• Eagles ML (+116)
• Panthers -5.5 (-108)

Two legs. Two mismatched lines. One plus-money parlay that feels like it should be chalk.

Referenced odds and lines are subject to change.